Adjunct to diet & exercise to improve glycemic control in patients w/ type 2 DM. May be used concomitantly w/ sulfonylureas or insulin to improve glycemic control.
Monotherapy or in combination w/ other oral antidiabetic agents Initially 500 mg once daily, may be increased in increments of 500 mg every 10-15 days based on blood glucose measurements. Max: 2,000 mg daily. If glycemic control is still not achieved, max dose: 3,000 mg daily. Combination w/ insulin Initially 500 mg once daily.
Lactic acidosis. Monitor CrCl &/or serum creatinine levels prior to initiating treatment & regularly thereafter. Discontinue use prior to, or at the time of iodinated contrast administration & not reinstituted until 48 hr afterwards & only after re-evaluated to normal renal function. Withhold therapy at least 48 hr prior to elective surgery w/ general spinal or peridural anaesth. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect on the ability to drive & use machines in combination w/ other antidiabetics (sulphonlyureas, insulin or meglitinides). Pregnancy & lactation. Elderly.
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